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KMID : 0941820100200010030
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Korean Journal of Clinical Pharmacy
2010 Volume.20 No. 1 p.30 ~ p.38
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Cost-Effectiveness of Paclitaxel plus Cisplatin as a Neoadjuvant Chemotherapy for Locally Advanced Head and Neck Cancer
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Sohn Hyun-Soon
Lee Tae-Jin
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Abstract
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This study was conducted to analyze cost-effectiveness of neoadjuvant chemotherapy for locally advanced head and neck cancer in Korean healthcare setting. We constructed a decision analytical model to estimate total costs and outcomes of paclitaxel+cisplatin (PC) or docetaxel+cisplatin+5-FU (DCF) for 2 years time horizon in 100 patient cohort with locally advanced head and neck cancer. Base analysis showed that cost savings of PC regimen were 379 million Korean Won and 231 million Korean Won in societal and payer’s perspectives, respectively, compared to DCF regimen, and life saved was 0.18. PC regimen as a dominant strategy was found to be robust through sensitivity analyses.
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KEYWORD
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cost-effectiveness, neoadjuvant chemotherapy, head and neck cancer, paclitaxel, docetaxel, cisplatin, 5-FU
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